ABSTRACT
Introduction: This study was conducted on 40 patients withsymptomatic cervical disc disease with one or two level discpathology. Clinical and radiological outcome was compared todetermine which technique was advantageous for treatment ofpatients with disc disease. Complications related to graft fusionfailures; subsidence, infection etc and donor site chronic painhave stimulated neurosurgeons to revert back to surgeries toavoid fusion.Methods: Patients were allocated to either ACD (n=21) orACDF (n=19) procedures. The standard Smith Robinsontechnique was performed in all patients in this study. Patientswere followed up clinically and radiologically according to thestudy protocol.Results: The clinical long term outcome was comparable inboth groups. Kyphosis and slow rate of fusion was noted withACD, but on long term follow up, patients were overallsatisfied. Donor site pain and graft related problems weremajor issues with ACDF. The issue of whether to fuse or not tofuse has not come to an end yet. This will require furtherrefinements in surgical technique, graft harvesting, and furtherstudies. Till then, both of these methods will be used forspecific indications.
ABSTRACT
Adult intussusception occurs infrequently and differs from childhood intussusception in its presentation, etiology, and treatment. Diagnosis can be delayed because of its long-standing, intermittent, and non-specific symptoms and most cases are diagnosed at emergency laparotomy. We report a case of 23-year-old female with complaints of abdominal pain, constipation, and loss of appetite since 2 months. Computed tomography revealed right colonic obstruction caused by intussusception of the ileocecum. On exploration, a mesenteric mass was seen extending with the intussusceptum following, which ileocecal intussusception was found. The mass was excised. Histopathology examination of the specimen revealed an inflammatory myofibroblastic tumor. These tumors can occur throughout the body, most commonly in the lung, mesentery, and omentum. Complete surgical resection is the treatment of choice. A Review of this rare condition is interesting and should be borne on the mind.
ABSTRACT
Hirayama disease also known as monomelic amyotrophy, primarily involves distal upper limb extremities. It differs from the known types of motor neuron diseases because of its nonprogressive behavior and pathologic findings of focal ischemic changes in the anterior horn of the lower cervical cord. We present a young male with Hirayama disease who had a left upper extremity involvement which was progressive in nature. He didn’t respond with initial treatment of cervical collar. Consequently surgical intervention improves muscle weakness and decrease the neurological deficit.
ABSTRACT
A rapid, stability-indicating reversed phase ultra-performance liquid chromatographic (RP-UPLC) method was developed for the determination of paliperidone palmitate (PP), in depot injectable dosage form. The chromatographic separation was achieved on an Acquity BEH C18 (50 mm × 2.1 mm, 1.7 μm) column, with a mobile phase consisting of ammonium acetate buffer, and acetonitrile at a ratio of 10:90 (v/v) and a flow rate of 0.6 mL/min. The eluted compound was monitored at a wavelength of 238 nm using a UV detector. The method described herein separated paliperidone palmitate from all other formulation components and two major known degradation products (N-Oxide and paliperidone) within a run time of 2.5 min. The method also generated linear results over a PP concentration range of 156 to 468 μg/mL. The stability indicating capability of the method was established by performing forced degradation experiments. The RP-UPLC method that was developed was validated according to the International Conference on Harmonization (ICH) guidelines. This method was successfully applied in the quantitative determination of PP in a stability study of paliperidone palmitate depot injection. The procedure described herein is simple, selective, and reliable for routine quality control analysis as well as stability testing.